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hematology management differential algorithm classification signs syndrome acute aplastic causes chronic cll comparison dermatology generalized hodgkins lymphoma mds mgus monoclonal
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... cytometry → >500/uL clonal ... of anemia or thrombocytopenia ... marrow failure with anemia ... #Leukemia #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... Leukemia): • Lymphocytes ... • Age: 60-80 Clonal ... #Hematology #Oncology ... #Diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... Lymphocytes) ... - Monoclonal Lymphocytes ... #Differential #Diagnosis ... Causes #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... phenomenon CLL Diagnosis ... • Neutropenia, anemia ... #Leukemia #diagnosis ... #workup #oncology
Signs and Symptoms of Acute Leukemia #Leukemia #Signs #Symptoms #Acute #Diagnosis #Oncology
Signs and Symptoms ... of Acute Leukemia ... #Leukemia #Signs ... #Symptoms #Acute ... #Diagnosis #Oncology
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
T-LGL leukemia - ... Large Granular Lymphocytic ... Neutropenia (85%), anemia ... LargeGranular #Lymphocytic ... #pathology #diagnosis
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
hypercalcemia) • Anemia ... - Clonal bone marrow ... plus one of: • Anemia ... • >60% plasma clonal ... #Management #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... Diagnosis: • Pancytopenia ... to MDS or acute leukemia ... #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... 10,000 new cases diagnosed ... cytopenias (usually anemia ... transformation to acute leukemia ... treatment #hematology #oncology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... hematology #WBC #Leukemoid
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