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diagnosis differential management msk orthopedics clinical endocrinology hepatology hypercalcemia hypomagnesemia low pathophysiology radiology syndrome alkaline alp chronic fever hematology hemophagocytic
Paget's Disease of Bone • Characterized by an ↑ rate of bone turnover with both excessive
of Bone • Characterized ... and formation of bone ... • Caused by ( ... more (polystotic) bones ... pelvis, and long bones
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... in Sickle Cell Disease ... Generally affects long bones ... BrighamChiefs #Bone ... Pain #SickleCell #Disease
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... excessive bone ... MSK • Deformed bones ... Lytic lesions make bones ... of middle ear bones
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... Dwarfism) • Hypothyroidism ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Hand X-Ray Anatomy and Interpretation Checklist 1. Soft tissues - Look carefully at the soft tissue over
tissue over all the bones ... Bones - All the ... bones of the hand ... in between the bones ... to the carpal bones
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... - Bone symptoms
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Differential Diagnosis Algorithm ... Granulomatous Disease ... Miscellaneous - Bone ... Hyperthyroid, Bony ... #causes #endocrinology
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... D) Increased bone ... vitamin A intake • Hyperthyroidism ... of bone Malignancy ... Multiple myeloma (bone
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... due to increased bone ... failure, Addison's disease ... , Hyperthyroidism ... Hypercalcemia #Causes
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