11 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Exogenous (KCL ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology ... #pharmacology #
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Aldosterone Release: ACE ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
Bradycardia - Differential Diagnosis Framework

BRADI Mnemonic
 • BRASH/Hyperkalemia
 • Reduced oxygen/Glucose/Temp
 • ACS
 • Drugs
 •
Mnemonic • BRASH/Hyperkalemia ... Glucose/Temp • ACS ... Infections BRASH Syndrome ... - Hyperkalemia ... diagnosis #causes #cardiology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... distal tubule. ↑ Nacl ... H+ secretion → Hypokalemia ... #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... Leukostasis: • Pathophysiology ... have fever - ACS ... : • Pathophysiology ... hydration - Hyperkalemia
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... - Hyperkalemia ( ... #Pathophysiology ... #cardiology
Causes of ST Segment Elevation - Differential Diagnosis Framework

STEMI:
 • Upsloping convex STE: "Pardee's sign" +
interval J Wave Syndromes ... involved • Brugada Syndrome ... Disorders: • Hyperkalemia ... no P waves • Hypercalcemia ... differential #diagnosis #cardiology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Encephalopathy Syndrome ... Clinico-Radiological Syndrome ... Blood transfusion, Hypercalcemia ... Etiology: • Pathophysiology ... circulation: MCA ACA
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... Inhibitors of Na+K+2Cl ... and nephrotic syndrome ... Hyponatremia • Hypercalcemia ... Diuresis #Nephrology #Pharmacology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... • Mitchell et al ... Acute Coronary Syndrome ... Differential #Diagnosis #Pathophysiology ... #causes #cardiology