39 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Neurologic-Centered ... Features: POEMS, AL ... Ig deposition disease ... #hematology #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... • Heavy Chain disease ... et diutinum Neurologic ... #Differential #Diagnosis ... #Oncology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
LC deposition disease ... significance (MGRS ... Minimal change disease ... #AKI #Cancer #Oncology ... #Differential #Diagnosis
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology ... #oncology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anti-Scl-70 - Scleroderma ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... #diagnosis #table ... #rheumatology #
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Significance (MGUS ... multiple myeloma, AL ... light-chain myeloma and AL ... #Significance #hematology ... #diagnosis #oncology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... Myeloma • MGUS ... • Fanconi's syndrome ... Minimal change disease ... #Proteinuria #Nephrology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
RED FLAGS - In all ... suspicion of severe disease ... splenomegaly, abnormal neurology ... Rheumatology ... Peds #Pediatrics #Diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
scleroderma) - Anti-Scl ... cases • Sjögren syndrome ... Antineutrophil #antibodies #diagnosis ... #rheumatology # ... diseases