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diagnosis hepatology algorithm criticalcare hematology transaminitis acidosis causes classification clinical enzymes function interpretation lactic management pathophysiology shock tests workup abnormal
Reference Laboratory Values - Fishbone Shorthand Complete Blood Count (CBC), Basic Metabolic Panel (BMP), Liver Function Tests
Reference Laboratory ... Values - Fishbone ... Metabolic Panel (BMP), Liver ... Function Tests (LFTs ... #Values #Labs #
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... more specific for hepatic ... • R value = (ALT ... #Enzymes #LFTs ... Transaminitis #diagnosis #differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... ) • Non-hepatic ... Function #Tests #LFTs ... #Differential #
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... Values and Interpretation ... Function #Tests #LFTs ... #Laboratory #Values
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects, Drugs, Liver ... Hypophostphatemia Laboratory ... Haptoglobin ↓ - Lactate
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... replaced by non-hepatic ... chemistry #diagnosis #differential ... transaminitis #LFTs
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... glucose by the liver ... to bolus these values ... - assess other laboratory ... Acidosis #Elevation #Differential
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... hepatorenal syndrome Clues ... sarcoidosis) • Liver ... metastasis • Fatty liver ... #Hypertension #Differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Calculate R-Value ... Drug #induced #Liver ... Idiosyncratic #differential
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
Shock - Differential ... malperfusion - Lactate ... Insufficiency, Liver ... Decompensated CHF, Severe Valve ... MAP > 60-65 2) Lactate
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