19 results
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... intake, Diuretics ... (late) • High ... Urine Cl-: Diuretics ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... intake, Diuretics ... (late) • High ... Urine Cl-: Diuretics ... Diagnosis #Algorithm #Nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Low intake • Metabolic ... Renal Losses: • Metabolic ... • HTN, High Aldosterone ... Loop and thiazide diuretics ... potassium #low #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
loop or thiazide diuretics ... pressure: Active diuretic ... use, Bartter syndrome ... , Gitelman syndrome ... urine #Algorithm #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypertensive: • High ... aldosteronism • High ... Al, High R - Secondary ... >20 mEq/24 h - Diuretics ... Diagnosis #Algorithm #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... • Inhibit Na+ Cl ... loss through the nephron ... #Pharmacology # ... nephrology #conversion
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
Mechanisms of nephron ... in cardiorenal syndrome ... activities • Diuretic ... release • ↓ Cl ... pathophysiology #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
resistance • Metabolic ... disequilibrium syndrome ... Inhibitors of Na+K+2Cl ... ; High-Ceiling Diuretics ... #Nephrology #Pharmacology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... distal tubule. ↑ Nacl ... delivery to distal nephron ... → Hypokalemia Metabolic ... Pathophysiology #nephrology
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
GI Losses - Gastric
 • Vomiting
 • NG suction
GI
Causes of Metabolic ... tubular transport • Diuretics ... Tumor Low Renin, High ... Licorice • Liddle's Syndrome ... MetabolicAlkalosis #NonGap #Nephrology