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oncology management ana antibody antinuclear erythematosus lupus nuclear patterns sle testing cd4 classification clues cytoplasmic differentiation disorders gap globulin hodgkins
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... Score • CML -> AML ... : Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... procedures - Infection ... not required in all ... #Diagnosis #Causes ... #Workup #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... initiation • Differential ... Diagnosis: Infection ... Differentiation #Syndrome #APML ... #hematology #oncology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... diagnoses, including ... search ANA and aPL ... Unexplained fever, when infection ... erythematosus #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Scl70 (in some cases ... Smith, Sm/RNP, Scl ... conditions - Sp-100, PML ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Pinpoint-sized red spots ... transformation to AML ... blood count with differential ... progression to AML ... #hematology #oncology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Lymphocytopenia DIAGNOSTIC ... myelodysplasia) • Infections ... #diagnosis #hematology ... #Differential # ... Causes #lymphocytopenia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Non-autoimmune rheumatologic ... #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... lymph node biopsy (diagnostic ... Immunohistochemical studies (to differentiate ... Hodgkins #lymphoma #diagnosis ... classification #hematology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Scl70 (in some cases ... Smith, Sm/RNP, Scl ... conditions • Sp-100, PML ... Nuclear #Patterns #differential ... #diagnosis #rheumatology
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