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diagnosis differential management causes hyperkalemia nephrology treatment hyperphosphatemia tumor acutekidneyinjury cairoandbishop clinical dislocation etiology framework hematology howardcriteria hyperuricemia hypocalcemia injury
Tumor lysis syndrome (TLS) - Pathophysiology: → Massive tumor cell lysis → Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... Massive tumor cell lysis ... ALL, AML, NHL → AKI ... #TLS #Pathophysiology
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Workup for Hyperphosphatemia ... • Endogenous: Rhabdomyolysis ... , Tumor lysis syndrome ... Kidney Disease: • AKI ... #phosphate #nephrology
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... tetany ↑UA = AKI ... #Syndrome #TLS ... #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... fever - ACS, AKI ... leukapheresis - TLS ... Syndrome: • Pathophysiology ... #Syndrome #TLS
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS ... #Workup #tumorlysissyndome
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Hemolysis • Rhabdomyolysis ... • Tumor lysis ... syndrome • Metabolic ... Elimination: • AKI ... blockers - MCW Nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... HIV, Influenza, TSS ... Dermatomyositis) AKI ... - Pathophysiology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - ... HIV, Influenza, TSS ... declines > ALT) • AKI ... + myoglobin AKI ... causes #treatment #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Acidosis, Cell Lysis ... (TLS, rhabdo/crush ... , RTA Type IV, AI ... reabsorption) Workup ... acidosis), CK+LDH (lysis
Posterior Knee Dislocation Injury Specifically, POSTERIOR KNEE DISLOCATIONS can have significant associated injury that needs unique approach
Neurologic deficit ... Brachial Index (ABI ... Neurologic injuries ... instability with lachmans ... WORK UP: obtain
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