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diagnosis differential causes management nephrology hyperkalemia hyperphosphatemia lysis treatment acutekidneyinjury algorithm cairoandbishop clinical dislocation etiology framework hematology howardcriteria hyperuricemia hypocalcemia
Tumor lysis syndrome (TLS) - Pathophysiology: → Massive tumor cell lysis → Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... ALL, AML, NHL → AKI ... #TLS #Pathophysiology
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Workup for Hyperphosphatemia ... • Endogenous: Rhabdomyolysis ... , Tumor lysis syndrome ... Kidney Disease: • AKI ... #phosphate #nephrology
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... tetany ↑UA = AKI ... #Lysis #Syndrome ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... fever - ACS, AKI ... leukapheresis - TLS ... • Pathophysiology ... #TLS #diagnosis
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS ... #Workup #tumorlysissyndome
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Hemolysis • Rhabdomyolysis ... • Tumor lysis ... syndrome • Metabolic ... Elimination: • AKI ... blockers - MCW Nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... HIV, Influenza, TSS ... Dermatomyositis) AKI ... - Pathophysiology
Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Respiratory Alkalosis, Tumor ... Genesis Syndrome ... Hyperparathyroidism, TKI ... Diagnosis #Algorithm #nephrology ... #phosphorus #workup
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - ... HIV, Influenza, TSS ... declines > ALT) • AKI ... + myoglobin AKI ... causes #treatment #nephrology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
• Acute stroke syndromes ... system: Brain tumor ... Lyme myositis • Rhabdomyolysis ... dystrophies Work ... Differential #Diagnosis #neurology
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