68 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... B-cell lineage ALL Symptoms ... -> AML: Blast crises ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Lymphoblastic Leukemia ... Reed-Sternberg Cells ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... transformation to acute leukemia ... only curative treatment ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... lymphocytes, smudge cells ... Constitutional symptoms ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... Skin: - CLL cells ... or basket cells ... microglobulin Treatment ... diagnosis #workup #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
pattern of spread, B symptoms ... Responsive to Treatment ... Treated Like Acute Leukemias ... growth, response to treatment ... Classification #pathophysiology
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Heart Failure Pathophysiology ... → Inflammation causes ... functional ID) Treatment ... improvement in symptoms ... diagnosis #management #cardiology
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
commonly hairy-cell leukemia ... Viral replication causes ... vascular endothelial cells ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... Dehydration • Symptoms ... Lysis Syndrome: • Pathophysiology ... Lysis of tumor cells
Traditionally, congestive heart failure has been classified according to severity of symptoms, first formulated by the
to severity of symptoms ... sometimes advanced treatment ... flare ups that cause ... III and class IV symptoms ... #Diagnosis #Cardiology