38 results
Mechanism of Action for Common Diabetes Medications

 • SGLT2i (Dapagliflozin)
 • TZD (Pioglitazone)
 • Biguanides (Metformin)
#Medications #pharmacology ... #pathophysiology ... #endocrinology
Sulfonylureas - Pharmacology Summary
Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... pancreatic beta cells ... Sulfonylureas #Pharmacology ... DM2 #diabetes #endocrinology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Hypokalemia - Differential ... Transcellular Shift Into Cells ... imports K+ into cells ... #Hypokalemia #Differential ... potassium #low #pathophysiology
Feedback Loop: Prolactin (PRL)
 • PRL levels exhibit diurnal, menstrual, and age-related variation
 • TRH has
maturation of immune cells ... • Alveolar Cells ... #FeedbackLoop #endocrinology ... #pathophysiology
Hyperkalemia Differential Diagnosis Algorithm
R/O Pseudo-hyperkalemia:
 • Possible Lab error! Alwavs Repeat Blood sample!
 • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... Thrombocytosis: cells ... 7) - principal cells ... #Hyperkalemia #Differential ... potassium #high #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview
LH and FSH are required for follicular development and
stimulates granulosa cells ... androgens from theca cells ... #OvarianCycle #pathophysiology ... #menstruation #endocrinology
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Pathophysiology: ... germinative skin cells ... Skin-homing T-cells ... Nikolsky #Algorithm #Differential
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
#hyperkalemia #differential ... #diagnosis #pathophysiology ... #pharmacology #
Drug-Induced Edema
Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
release from mast cells ... Medication #Causes #Differential ... #Pharmacology # ... Pathophysiology
Asthma: immunopathogenesis. 
Allergens attach to, and are taken up by, dendritic cells that he the respiratory
by, dendritic cells ... T-helper (TH2) cells ... . which differentiate ... into plasma cells ... immunopathogenesis #Pathophysiology