44 results
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Characterized by red blood cells ... These cells can ... The underlying pathophysiology ... sequestration of sickle cells ... Features #Signs #Symptoms
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
mutated in one cell ... mutated in all cells ... Retinoblastoma Signs / Symptoms ... Retinoblastoma #pathophysiology ... diagnosis #signs #symptoms
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
B and CD-4+ T cells ... CRP Neuronal cell ... surface targeted -> Cell ... RheumaticFever #pathophysiology ... diagnosis #signs #symptoms
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Reed-Sternberg (RS) Cells ... Lymphocyte - 5% RS cells ... (LP) tumour B cells ... pattern of spread, B symptoms ... Classification #pathophysiology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... old; F>M Signs/Symptoms ... Anemia - Giant cells ... Temporal #Arteritis #Pathophysiology ... Diagnosis #Signs #Symptoms
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood cells ... age 70 years Symptoms ... abnormal under the microscope ... abnormal under a microscope ... abnormal under the microscope
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
maturation of B cells ... from precursor cells ... immunity Signs/Symptoms ... Absence of mature B cells ... CD19+) and plasma cells
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
depolarization in fast AP cells ... depolarization in slow AP cells ... depolarization in slow AP cells ... Classification #Classes #cardiology ... #pharmacology
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
the mastoid air cells ... and mastoid air cells ... in mastoid air cells ... #Mastoiditis #pathophysiology ... #signs #symptoms
Hashitoxicosis

‘Leakage’ symptoms of active Hashimoto’s disease

- Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in
Hashitoxicosis ‘Leakage’ symptoms ... lymphocytes and plasma cells ... ‘Leakage’ symptoms ... due to thyroid cell ... Endocrinology #Diagnosis #Pathophysiology