31 results
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... vasculitis • Hematologic ... criteria for 1) hematologic ... peripheral blood myeloid ... cells NEJM Review
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Erythroderma - Diagnostic ... of germinative skin ... Causes: 1) Exfoliative ... T-cells #Diagnosis ... #Dermatology #Rash
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
- Differential Diagnosis ... similarly to mast cells ... Chickenpox Other Causes ... #Differential #Diagnosis ... #causes #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... - Differential Diagnosis ... Formation • Multiple Myeloma ... Macrocytosis, Target Cells ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... Management Summary myelo ... = funny-shaped cells ... old, ~10,000 new cases ... Management #treatment #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
for secondary causes ... eosinophilia (common causes ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
fashion- onion skin ... Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
Scleroderma Like Conditions - Differential Diagnosis
Eosinophilic Fasciitis:
 - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... lymphocytes, plasma cells ... setting of multiple myeloma ... #Differential #Diagnosis ... comparison #table #dermatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Differential Diagnosis ... Testosterone - Coumadin skin ... coagulation and other causes ... pathophysiology #hematology ... #differential #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... -> AML: Blast crises ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis