38 results
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... demineralization) • Renal disease ... osteolytic lesions and pathologic ... marrow plasma cells ... #oncology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... thrombocytopenia, multiple myeloma ... conditions - multiple myeloma ... peripheral blood myeloid ... cells NEJM Review
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... Diffuse plasma cells ... cell disorders (myeloma ... #Variants #Diagnosis ... #Pathology
Back Pain - Differential Diagnosis
Primary Back Pathology:
 • Musculoligamentous injury (a.k.a. lumbosacral strain)
 • Spondylosis (i.e.
- Differential Diagnosis ... Primary Back Pathology ... to metastatic disease ... Systemic Diseases ... , thyroid, and myeloma
IgG4-associated conditions

Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
conditions Diagnosis ... really need to see pathology ... positive plasma cells ... Even the pathology ... #differential #diagnosis
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... ULN R - Renal disease ... chain deposition disease ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
Syphilis, Lyme disease ... POEMS syndrome, myeloma ... Charcot-Marie-Tooth, Fabry's disease ... Leah Willis via ... #differential #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... Management Summary myelo ... = funny-shaped cells ... 10,000 new cases diagnosed ... treatment #hematology #oncology
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Pathologic / Fragility ... - Differential Diagnosis ... - Skull/spine/Pelvis ... Fragility #Fractures #Pathologic ... #Differential #Diagnosis
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome • Myeloid ... appearing during the disease ... #differential #diagnosis ... #dermatology #oncology