28 results
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... - Warm vs Cold ... or negative - Smear ... : spherocytes Cold ... #diagnosis #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Differential Diagnosis Algorithm ... Abnormal peripheral smear ... Differential #Diagnosis #Algorithm ... #hematology
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... Microangiopathic hemolytic ... Peripheral #Blood #Smear ... #Analysis #hematology ... #microscopy #interpretation
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
polychromatophilic cells ... arrow) Peripheral smear ... #anemia #Hematology ... #Pathology #Smear ... #Microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Differential Diagnosis Algorithm ... Peripheral blood smear ... History • Bite cells ... Deficiency • Sickle cells ... Differential #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... Complement-Mediated • Cold ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... IgM) • Blood smear ... sensitize red blood cells ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... • Sickle cells ... Agglutination - Cold ... Differential #Diagnosis #Algorithm ... #workup #hematology
A non-subtle example of true Sezary syndrome.  Patient presented with erythroderma without antecedent history of
Sezary #Syndrome #Cells ... Clinical #Pathology #Smear ... #Microscopy #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Differential Diagnosis Algorithm ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... Differential #Diagnosis #Algorithm ... #Causes #Hematology