9 results
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... cells can infiltrate ... Paraneoplastic phenomenon ... smear: Smudge cells ... or basket cells
Hashitoxicosis

‘Leakage’ symptoms of active Hashimoto’s disease

- Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in
lymphocytes and plasma cells ... ‘Leakage’ symptoms ... due to thyroid cell ... in ‘Leakage’ phenomenon ... Endocrinology #Diagnosis #Pathophysiology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
• Langerhan cells ... removal of these cells ... Vasculitis, Raynaud's Phenomenon ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... varied clinical symptoms ... hormone in almost all ... (shown in the video ... in the muscular belly
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... : 1) T-cell dysfunction ... and increased B-cell ... tissue: Epithelioid cells ... : (distinct symptoms
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Release from blast cells ... • Induce blast cell ... Diagnosis: >3 symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
polymorphisms alter cell-mediated ... various inflammatory cells ... nephrotic/nephritic syndrome ... HenochScholeinPurpura #Pathophysiology ... Diagnosis #Signs #Symptoms
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... invades mononuclear cells ... CNS ○ Infected cells ... • Depressive symptoms ... The clinical syndrome
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
overgrowth of cells ... Angioimmunoblastic T cell ... lymphoma Pathophysiology ... and the systemic symptoms ... mature plasma cells