21 results
management hematology neurology differential hemeonc leukemia syndrome aids chronic classification hemophagocytic hiv hlh infections infectiousdiseases lymphocytic lymphohistiocytosis mds myelodysplastic workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... leukostasis syndrome: CNS ... ) CLL Symptoms: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... microglobulin Treatment ... Lymphocytic #Leukemia #diagnosis ... #workup #oncology ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... Allogeneic stem cell ... only curative treatment ... #Management #treatment ... #hematology #oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Disease, PRES Pathophysiology ... permeability Diagnosis ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... minimal tumor burden Diagnosis ... lymphocytes, smudge cells ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Responsive to Treatment ... growth, response to treatment ... Classification #pathophysiology ... #Hematology #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Release from blast cells ... • Induce blast cell ... #oncology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
- Differential Diagnosis ... per μL • Diagnosis ... Antimicrobial treatment ... #differential #diagnosis ... InfectiousDiseases #Neurology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... lymphoma, B-cell ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
“big & sticky” cells ... ) - Symptoms: CNS ... ) - Symptoms: CNS ... ± tocilizumab; call ... #HemeOnc #Diagnosis
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