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Treatment Approach to Hodgkin's Lymphoma

By Matthew Ho, MD PhD @MatthewHoMD
With Credit: Dr Sunita Nasta and Dr
Treatment Approach ... to Hodgkin's Lymphoma ... guidelines #Hodgkins ... #Lymphoma #oncology ... #Hematology #management
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Hodgkin's Lymphoma ... Hodgkin's Lymphoma ... , Hodgkin Lymphomas ... • Other hematologic ... #comparison #oncology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin's Lymphoma ... Hodgkin Lymphoma ... Lymphoma Treatment ... classification #hematology ... #oncology #management
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Fatigue • Acute ... Lymphocytes) - Monoclonal ... Cells on Biopsy ... Algorithm #Causes #Hematology ... #Oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Diagnosis Algorithm Hodgkin ... Depletion Non-Hodgkin ... Responsive to Treatment ... Treated Like Acute ... pathophysiology #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... microglobulin Treatment ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... tubulopathy • Monoclonal ... change disease • Hematologic ... malignancies Treatment ... #AKI #Cancer #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... transformation to acute ... only curative treatment ... #hematology #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... Rebound effect from treatment ... Metastatic cancer, Lymphoma ... Kawasaki, Nephrotic syndrome
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... Marginal Zone Lymphoma ... Marginal zone lymphoma ... Paraproteinemias #Hematology ... #Diagnosis #Oncology