19 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
disease (MCTD), Drug-induced ... (SLE), Sjogren's ... (SLE), Systemic ... #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... Mimickers: Drug-induced ... #Diagnosis #autoantibodies ... #rheumatology
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Lupus Erythematosus ... Lupusreference #DrugInduced ... #pharmacology # ... risk #differential ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... alopecia Differential ... Arthritis: • Joint pain ... extremities Drug ... #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... of autoantibodies ... Systemic Lupus Erythematosus ... Lupusreference #druginduced ... #table #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... Systemic lupus erythematosus ... disease (MCTD), Drug-induced ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
(60-70%) & drug-induced ... higly specific for SLE ... #Antinuclear #autoantibodies ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
fingers, or pain ... the face (many differential ... has been ruled out ... clues #system #erythematosus ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... morning • Effusion leukocyte ... arthritis • SLE ... #Differential # ... Diagnosis #MSK #rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Aortitis - Differential ... Polyarteritis Nodosa (PAN ... Systemic lupus erythematosus ... (SLE), Sarcoidosis ... #Diagnosis #rheumatology