12 results
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Types: • Leukocyte ... - Allergic ... proteins on plts, leukocytes ... diagnosis #management #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... the banked donor blood ... • Allergic reaction ... proteins on plts, leukocytes ... diagnosis #management #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... syndrome, POEMS • Reaction ... post-splenectomy, Exercise, Allergic ... reactions Matthew
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Mechanism of Action: Allergen-specific ... Examples: Acute transfusion ... recruitment of leucocytes ... #types #allergy
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... Reactions TRALI ... plasma volume transfusion ... of high parity blood ... #Reactions #hematology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
When the specific allergen ... - Red blood cell ... destruction after transfusion ... with mismatched blood ... #Diagnosis #Reactions
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... released during an allergic ... reaction or asthma ... Or Inflammatory Reactions ... Diagnosis #causes #hematology
Thromboelastography (trademarked as TEG)
 • Graphical representation of the fibrin polymerization process
 • Point-of-care anti-coagulation monitoring
determining if transfusion ... of blood products ... need for specific blood ... patients) R (reaction ... interpretation #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
AIHA, Cold AIHA, Transfusion ... reactions, Drug-associated ... - Peripheral Blood ... Differential #Diagnosis #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... causes are asthma, allergy ... , drug reaction, ... Differential #diagnosis #hematology