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anemia blood leukemia product reactions thrombocytosis aplastic classification cll coagulation dic diffuse disseminated evaluation extravascular hemolysis hemolytic hodgkins lad lymphadenopathy
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... , Hematology 2012 ... , p 193 #Diagnosis ... #Differential # ... Algorithm #Thrombocytopenia
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... effect following treatment ... following EtOH induced thrombocytopenia ... #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Causes Intravascular ... microangiopathy: Thrombotic thrombocytopenic ... #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Diagnosis Algorithm ... Non-lmmune: • HELLP Syndrome ... Diagnosis #Algorithm ... #Causes #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... Age > 50 • Chronic ... #Diagnosis #Algorithm ... #Causes #Hematology ... #Oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... for workup, including ... #Diagnosis #Algorithm ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treat primary cause ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... infiltrates (anemia, thrombocytopenia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Neutropenia, anemia, thrombocytopenia ... microglobulin Treatment ... #workup #oncology ... #hematology
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