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diagnosis hepatology transaminitis bilirubin causes hepatitis management acutekidneyinjury aki chemistry congenital conjugated criticalcare dili direct drug function hepatocellular idiosyncratic induced
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... or symptoms of liver ... Drug #induced #Liver ... #differential # ... #algorithm #gastroenterology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... (Drug-induced liver ... injury) • Ischemic ... LouLectures #Liver
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
to Conjugated Hyperbilirubinemia ... - Differential ... Diagnosis Algorithm ... MRCP, ERCP, liver ... #gastroenterology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... #Injury #Differential ... Transaminitis #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Interpretation of LFTs ... Liver Failure ( ... chemistry #diagnosis #differential ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Liver Injury: ... Liver Injury: ... Liver Injury:
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Hepatocellular - Liver ... Artery: Shock Liver ... #Injury #Differential ... #algorithm #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... #Patterns #Liver ... #LFTs #transaminitis ... #differential #
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
UGT1A1 activity level ... of hemolysis or liver ... injury ... symptoms, such as abdominal ... hepatology #diagnosis #gastroenterology
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
Shock - Differential ... Insufficiency, Liver ... Medications, Spinal Cord Injury ... Severe auto-PEEP, Abdominal ... #criticalcare #algorithm
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