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diagnosis hematology causes injury workup dermatology hepatitis rheumatology systemic transaminitis classification disorders infections laboratory mcv pruritus secondary testing treatment ascites
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... hepatomegaly and anemia ... cholestasis: • Fever ... liver failure ... Liver transplant
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
of Chronic Disease ... of Chronic Disease ... Renal Disease, Liver ... Reticulocytosis • Liver ... #Causes #Hematology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Cirrhosis • Chronic ... Hepatopathy • Acute ... (Drug-induced liver ... Diagnosis #hepatology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
- Anemia of chronic ... disease - Vitamin ... disorder - TSH, LFTs ... #hematology #diagnosis ... #differential #
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Folate deficiency, Liver ... , Liver disease, ... liver disease, ... RBC #Morphology #differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... - ongoing ↑ LFTs ... or symptoms of liver ... disease 6-9 mo ... Drug #induced #Liver
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypothyroid • Liver ... Disease • Alcohol ... #differential # ... diagnosis #algorithm ... #hematology #workup
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
disease, Acute ... : Alcohol use, Liver ... disease (independent ... morphologic #mcv #differential ... diagnosis #causes #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 ... • NASH, Chronic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... disease, liver ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology
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