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diagnosis rheumatology erythematosus causes management arthritis dermatology pain symptoms msk neurology algorithm classification criteria oncology cardiology disease leukemia monoarticular pulmonary
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... : Fever (50%), Depression ... Demyelinating syndromes ... #SLE #systemic ... erythematosus #signs
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... Vasculitis -> Acute ... - Budd Chiari Syndrome ... #SLE #Gastrointestinal ... pathophysiology #signs
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... fever • Mononeuritis ... • New murmur, fever ... #pain #differential
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Constitutional domain: Fever ... , Acute cutaneous ... in at least 2 joints ... Classification #Criteria #SLE ... #Systemic #Lupus
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
• Rheumatic Fever ... Lupus Erythematosus ... Sicca) Syndrome ... • Rheumatic Fever ... Acute Onset
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... • Rheumatic fever ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... #rashes #differential
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... [SLE], AOSD) • ... ALT ↑ bilirubin level
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Malar rash 40% - Fever ... #Systemic #Lupus ... autoantibodies #signs ... #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
rheumatic fever ... spondyloarthropathies, lupus ... Chronic = RA, SLE ... approach #workup ... #differential #
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
Systemic Lupus Erythematosus ... (SLE) - Typical ... Signs/Symptoms ... Alopecia, Fever, ... #SLE #Signs #Symptoms
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