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Table of Causes of Acute Liver Injury
#Diagnosis #Hepatology #Acute #Liver #Injury #Causes #Differential #Incidence #Table #Failure
Liver Injury #Diagnosis ... #Hepatology #Acute ... #Liver #Injury ... #Causes #Differential ... Incidence #Table #Failure
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Liver Injury ... Transaminitis #diagnosis #differential ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Hepatopathy • Acute ... (Drug-induced liver ... injury) • Ischemic ... Diagnosis #hepatology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... cholestasis: • Fever ... liver failure ... Liver transplant ... Hepatobiliary #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Liver Failure ( ... months without treatment ... disease, liver ... Injury (DILI) ... #Hepatology #gastroenterology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Liver Injury ... - Drug-Induced liver ... injury - Viral ... #Causes #Differential ... #Hepatology #Diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injuryliver ... Injury Differential ... #Injury #Differential ... #Diagnosis #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... > 20x normal - Acute ... #Patterns #Liver ... #Injury #hepatology ... #differential #
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... Liver Failure ( ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... or symptoms of liver ... Drug #induced #Liver ... #differential # ... gastroenterology #hepatology