66 results
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... Supportive with treatment ... cholestasis: • Fever ... Hepatobiliary #hepatology ... #hepatitis #differential
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Injury - Ichemic ... injury - Viral ... hepatitis - Wilson disease ... Acute #Causes #Differential ... #Hepatology #Diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... disease 6-9 mo ... #differential # ... Diagnosis #Management ... gastroenterology #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... disease, liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injuryliver ... Injury Differential ... #Injury #Differential ... #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... Syndrome, Celiac Disease ... , Infiltrative Disease ... #Injury #Differential ... Acute #algorithm #hepatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad: Fever ... fraction < 20% Differential ... #diagnosis #management ... #treatment #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... Treatment: • Corticosteroids ... #Hematology #Rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Venoocclusive disease ... #differential # ... diagnosis #algorithm #hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Veno-occlusive disease ... Liver disease ... Mediterranean fever ... Causes #diagnosis #differential ... #hepatology #SAAG