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diagnosis hematology treatment comparison signs syndrome oncology cardiology causes infectiousdiseases neurology lupus pulmonary sle dermatology erythematosus hemophagocytic hlh infections lung
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... ALT ↑ bilirubin level ... Syndrome #Diagnosis #Management
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... : Fever, Arthralgia ... fraction < 20% Differential ... solid cancers • Systemic ... #diagnosis #management
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... (SLE) General: Fever ... pain (20%) Renal disease ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Approach to Eosinophilic Lung Diseases • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
initiation of smoking; Fever ... brown sputum, fever ... Travel hx, food hx; Fever ... #pulmonary #differential ... diagnosis #comparison #table
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Malar rash 40% - Fever ... autoantibodies #signs #symptoms ... #mimickers #differential ... #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... SLE, Rheumatic fever ... stenosis - Rheumatic fever ... • New murmur, fever
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Systemic inflammation ... correlates with time of fever ... Daily high spiking fever ... - Fever spikes ... Fever of at least
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
life Causes and clinical ... and duration of symptoms ... - Headache, fever ... Urticaria #diagnosis #rheumatology ... #comparison #table
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... - Pel-Ebstein fever ... Noncontiguous spread • Clinical ... involvement Differential ... #hematology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
: High spiking fever ... episode (30%) Systemic ... AOSD: high fever ... #AOSD #rheumatology ... #diagnosis #management
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