10 results
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... #DrugInduced #Liver ... #Injury #Pathophysiology ... #hepatology
Shotgun Laboratory Testing for Severe Acute Livery Injury

https://www.journalofhospitalmedicine.com/jhospmed/article/143598/hospital-medicine/ammonia-levels-and-hepatic-encephalopathy-patients-known

#TWDFNR #Testing #Laboratory #LiverInjury #Diagnosis #Workup #Hepatology #EBM #ChoosingWisely
Shotgun Laboratory ... for Severe Acute Livery ... Injury https ... LiverInjury #Diagnosis #Workup ... #Hepatology #EBM
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... nucleotidase - Liver ... hepatocellular injury ... #Tests #LFTs #Laboratory ... Interpretation #diagnosis #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... AlkPhos #Bilirubin #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... cholestasis → Cirrhosis/Liver ... failure PBC Signs ... or higher • Liver ... #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... hepatocellular pattern of liver ... injury, though ... Necrosis) If mild laboratory ... Diagnosis #Management #Hepatology
Acute-phase Reactants Synthesized in the Liver 
Positive acute-phase reactants (concentrations increase with acute inflammation)
 - Immune-related
Synthesized in the Liver ... #Synthesized #Liver ... #Synthesis #Hepatology ... #pathophysiology ... #Laboratory
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Syndrome, Ischemic Liver ... Vasculitis • Injury ... Venous #Arterial #pathophysiology ... #hematology #differential
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... venipuncture sites Laboratory ... DIC • Severe Liver ... treatment #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Presentation • Common Signs ... - Elevated liver ... Pathophysiology ... Fever b. ... Diagnosis #Management #Hematology