21 results
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... change disease • Hematologic ... malignancies Treatment ... Methotrexate • AIN ... #AKI #Cancer #Oncology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Manifestations of Sickle Cell ... sickle cell hepatic ... pain, jaundice ... Supportive with treatment ... Hepatobiliary #hepatology
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
Medications causing ... Acute Kidney Injury ... , tenofovir • AIN ... #Acute #Kidney ... #Drugs #pharmacology
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... cardiorenal syndrome) • Liver ... nephritis (AIN) ... tract infection • Medications ... #Acute #Kidney
Acute Kidney Injury (AKI) - Management Principles
Prerenal - Correct hemodynamic derangements:
 • If low preload →
Acute Kidney Injury ... (AKI) - Management ... Treat underlying liver ... • AIN → Consider ... #Acute #Kidney
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Acute leukemias ... infections, bone pain ... , fever, joint pain ... #Leukemia #Hematology ... #Oncology #Diagnosis
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... death Neutropenic Fever ... neutrophil count < 500 cells ... New-onset back pain ... Hyperuricemia • Acute
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... : • Common: fever ... diagnosis #management #hematology ... #oncology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Indications Treatment ... ) • Use of B-cell ... immunosuppression • Acute ... > 3 mg/dL) or acute ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... duration), Several medications ... non-essential drug/HDS treatments ... dechallenge • Acute ... Diagnosis #Algorithm #hepatology