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Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Kidney Injury (AKI ... change disease • Hematologic ... malignancies Treatment ... Methotrexate • AIN ... #Cancer #Oncology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Hyperviscosity Syndrome ... death Neutropenic Fever ... New-onset back pain ... Dyspnea, chest pain
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
a.k.a. cardiorenal syndrome ... ) • Liver failure ... a.k.a. hepatorenal syndrome ... interstitial nephritis (AIN ... tract infection • Medications
Acute Kidney Injury (AKI) - Management Principles
Prerenal - Correct hemodynamic derangements:
 • If low preload →
Kidney Injury (AKI ... • Hepatorenal syndrome ... Treat underlying liver ... → No specific treatment ... • AIN → Consider
Atopic Dermatitis - Topical Treatment Options 
First Line: Topical Corticosteroids 
  - High Potency: Betamethasone
Dermatitis - Topical Treatment ... After non-pharmacologic ... has a different level ... #Medications #Pharmacology ... #Dermatology #Management
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
malaise) - Muscle pain ... Inflammation and pain ... , breast CA - Hematologic ... Treatment: - Systemic ... #oncology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
is the main clinical ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
Pneumonia - Typhoid fever ... respiratory distress syndrome ... InfectiousDiseases #Infections #Pharmacology ... #Management #Treatment ... #Indications
ED Opioid Stewardship Algorithm

Opioid Naive vs Opioid Tolerant

1. Patient Specific, Pain Syndrome-Targeted Approach
2. Combinations of Non-Pharmacologic
Patient Specific, Pain ... Syndrome-Targeted ... Combinations of Non-Pharmacologic ... Medication Assisted ... Treatment (MAT)
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... - ACS, AKI, ... organ damage • Treatment ... Low calcium • Treatment ... diagnosis #management #hematology