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management differential classification criticalcare overview pharmacology syndrome toxicity aspirin clozapine coagulation dic disseminated diuresis diuretics elevation excretion hematology intravascular lactate
Occult Causes of Non-Response to Vasopressors vital disclaimer: the cognitive response to hypotension should not be reaching
hypotension is treatment ... non-responders: - acidosis ... occult bleeding - toxicologic ... - 2nd cause shock ... #Diagnosis #Nonresponse
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
glucose by the liver ... contribution of liver ... ->treatments include ... mellitus/DKA - Liver ... gluconeogenesis Liver
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
Salicylate Toxicity - Diagnosis ... no respiratory cause ... Pulmonary edema, Shock ... Aspirin #Toxicity #Toxicology ... #Treatment
Streptococcal Toxic Shock Syndrome (STSS) Complication of invasive GAS disease characterized by shock & MOF → occurs
GAS in 30% of cases ... 50% in nec fasc Diagnostic ... (2+): kidneys, liver ... necrosis STSS Treatment ... #management #diagnosis
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
Shock Overview ... Renal: metabolic acidosis ... AI, thyroid dz liver ... Classification #diagnosis ... #differential #causes
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
Shock Overview ... Renal: metabolic acidosis ... AI, thyroid dz liver ... Classification #diagnosis ... #differential #causes
Clozapine Toxicology Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... metabolized in the liver ... Clozapine is known to cause ... #Toxicity #Diagnosis
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
heart failure, liver ... heart failure, liver ... Kidney stones caused ... heart failure, liver ... heart failure, liver
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (16%) • Shock ... DIC • Severe Liver ... Treat primary cause ... #Coagulation #diagnosis ... #causes #treatment
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Diagnosis ... Hypocomplementemia • Can cause ... vasculitis: 10%-16% Liver ... renal tubular acidosis ... Adenocarcinoma Treatment
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