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management differential classification criticalcare overview pharmacology syndrome toxicity aspirin clozapine coagulation dic disseminated diuresis diuretics elevation excretion hematology lactate lactic
Occult Causes of Non-Response to Vasopressors vital disclaimer: the cognitive response to hypotension should not be reaching
hypotension is treatment ... non-responders: - acidosis ... occult bleeding - toxicologic ... - 2nd cause shock ... #Diagnosis #Nonresponse
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
glucose by the liver ... contribution of liver ... ->treatments include ... mellitus/DKA - Liver ... gluconeogenesis Liver
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
Salicylate Toxicity - Diagnosis ... no respiratory cause ... Pulmonary edema, Shock ... Aspirin #Toxicity #Toxicology ... #Treatment
Streptococcal Toxic Shock Syndrome (STSS) Complication of invasive GAS disease characterized by shock & MOF → occurs
GAS in 30% of cases ... 50% in nec fasc Diagnostic ... (2+): kidneys, liver ... necrosis STSS Treatment ... #management #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... dysfunction (16%) • Shock ... DIC • Severe Liver ... #Coagulation #diagnosis ... #causes #treatment
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
Shock Overview ... Renal: metabolic acidosis ... AI, thyroid dz liver ... Classification #diagnosis ... #differential #causes
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
Shock Overview ... Renal: metabolic acidosis ... AI, thyroid dz liver ... Classification #diagnosis ... #differential #causes
Clozapine Toxicology Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... metabolized in the liver ... Clozapine is known to cause ... #Toxicity #Diagnosis
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
heart failure, liver ... heart failure, liver ... Kidney stones caused ... heart failure, liver ... heart failure, liver
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Diagnosis ... Hypocomplementemia • Can cause ... vasculitis: 10%-16% Liver ... renal tubular acidosis ... Adenocarcinoma Treatment
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