33 results
Ethacrynic acid - Conversion
Only loop diuretic without a sulfonamide substituent.
Rarely used alternative in patients who have
Ethacrynic acid - Conversion ... Only loop diuretic ... Ethacrynic #acid #Conversion ... #pharmacology #indications ... #diuretics #loop
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... . mannitol) 3) Loop ... diuretic (e.g. ... Metolazone) 5) Potassium-sparing ... pharmacology #nephrology #medications
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP ... DIURETICS • Furosemide ... Chlorthalidone POTASSIUM-SPARING ... #Medications #Pharmacology
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Saline or osmotic diuresis ... - Potassium depletion ... disease Drugs: - Loop ... #differential #medications ... #pharmacology #hypomg
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Metolazone Loop ... Piretanide Potassium ... Pharmacology #nephrology #conversion ... #loop #thiazide
Diuresis in Critical Care - Achieving a Negative Fluid Balance
Advantages Of A Negative Fluid Balance:
 •
TO PO • USE HIGH ... CONCENTRATION MEDICATIONS ... • Start with LOOP ... ) to normalize Potassium ... especially in high
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Renal Loses - Medications ... - Loop and ... thiazide diuretics ... Post-obstructive diuresis ... Causes #Workup #hypomg
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
- Insulin (high ... Furosemide and other loop ... diuretics ... hypomagnesemia #Medications ... nephrology #Causes #hypomg
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... Syndrome • HTN, High ... • HTN Absent: Loop ... and thiazide diuretics ... #causes #potassium
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic algorithm ... • Drugs • Diabetic ... Normal, Renin High ... hypoplasia Aldosterone high ... Hyperkalemia #Diagnosis #algorithm