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Presentation of malignant disease in children Pre-school (<5 years old) - Acute lymphoblastic leukaemia
old) - Acute lymphoblastic ... leukaemia - (ALL ... School-aged - Acute lymphoblastic ... leukaemia (ALL) ... leukaemia (ALL)
B-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma Clinical - Primarily a disease of childhood, 75% <6 yo - Increased
B-Cell Acute Lymphoblastic ... Leukemia/Lymphoblastic ... iAMP21 - BCR-ABL-like ... lauraebrown #BCell #ALL ... #LBL #Acute #Lymphoblastic
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Standard-Risk Acute Lymphoblastic ... Cytarabine #ALL ... #Acute #Lymphoblastic
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
• Acute Lymphoblastic ... Leukemia (ALL) ... Myeloid Leukemia (AML
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL (Acute Lymphoblastic ... age • 75% of ALL ... B-cell lineage ALL ... Mature B-cell ALL ... involvement • T-cell ALL
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT ... /ULN ALT) / (Alk ... phos/ULN ALP) ... Liver Failure (ALF ... • AST/ALT > ALP
Indolent T-Lymphoblastic Proliferation (iT-LBP) Features of iT-LBP: - May be seen in association with other malignancies (e.g.
Indolent T-Lymphoblastic ... similarities to T-lymphoblastic ... iTLBP #Indolent #TLymphoblastic
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
kidney, brain ALT ... for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP)
Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview Mechanism: Glycopeptide - inhibits cell wall synthesis
inhibits cell wall ... beta lactams – D-Ala-D-Ala ... Used for: all sorts
Heme Synthesis Pathway Enzymes 1. ALA Synthase 2. ALA Dehydratase 3. Porphobilinogen deaminase 4. UP Ill Synthase 5. UP Ill Decarboxylase 6. Coproporphyrinogen
ALA Synthase 2. ... ALA Dehydratase ... UP Ill Synthase ... UP Ill Decarboxylase
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