125 results
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
CTx - marker of bone ... resorption • Lytic ... bone lesions (mostly ... formation #PagetsDisease ... pathophysiology #diagnosis #signs
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
cause excessive bone ... turnover -> Incr bone ... Osteoarthritis • Lytic ... hearing loss #PagetsDisease ... pathophysiology #diagnosis #signs
Diagram of different types of bone tumors that can occur around the knee on XRay -
different types of bone ... blastic or mixed lytic-blastic ... Paget disease - lytic ... blade of grass sign ... Aggressive lesion - lytic
Diagram of different types of bone tumors that can occur around the knee on XRay
Age <
different types of bone ... blastic or mixed lytic-blastic ... Paget disease - lytic ... blade of grass sign ... Aggressive lesion - lytic
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... • Aneurysmal Bone ... Fibroma Multiple Lytic
Basilar Skull Fracture
Fracture through petrous portion of temporal bone 
 - Periorbital ecchymosis 
 - Hemotympanum
portion of temporal bone ... ecchymosis (Battle's sign ... Fracture #Battles #Signs
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
in subchondral bone ... architecture -> Palpable bony ... contact between bony ... pathophysiology #diagnosis #signs
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... metastasized to the bone ... • Metastatic bone ... Signs/Symptoms:
Gardner's Syndrome
Multiple pre-malignant colonic polyps with soft tissue & bony tumours. Associated with mutation to the
soft tissue & bony ... Polyposis #Diagnosis #Signs
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
3: Necrosis of bone ... destroying thin bony ... of the temporal bone ... inner cortical bone ... pathophysiology #signs