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diagnosis sle ana antibody antinuclear erythematosus oncology patterns systemic testing associations autoantibodies causes cytoplasmic disorders druginduced drugs hcq hodgkins hydroxychloroquine
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... ANA (anti-nuclear ... Anti-cardiolipin (aCl ... Anti-centromere, Scl ... Autoantibodies #Rheumatology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
probably < 1500ng/mL ... Best indications ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antibody Testing - Nuclear ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... family history - Medications ... changes), high MCV ... not required in all ... Causes #Workup #hematology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antibody Testing - Nuclear ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... #Patterns #differential ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... La, anti-Jo-1, SCL ... activation and/or medications ... Erythematosus #Diagnosis #Rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Non-Hodgkin's Lymphoma - Comparison ... Malignancies (eg CML ... , ALL) • Solid ... #NonHodgkins #comparison ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & MBL ... Evans • ITP • Cl-NH ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Induced Systemic Lupus ... Erythematosus #medications ... #drugs #pharmacology ... #risk #differential ... #diagnosis #rheumatology
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