39 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Anti-cardiolipin (aCl ... glycoprotein I (ß2GP), Lupus ... Anti-centromere, Scl
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... disease (MCTD), Drug-induced ... Antinuclear #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Medications associated with drug-induced lupus

List of Definite and Possible Associated Drugs

#Diagnosis #Pharmacology #Medications #DrugInduced #Lupus #List
Medications associated ... lupus List of ... Definite and Possible ... #Diagnosis #Pharmacology ... #Differential #
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
and probably < ... Best indications ... #rheumatology # ... pharmacology #levels ... #lupus #management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... lupus cases, drug-dependent ... thiazidic, PPI, ACE ... #table #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Auto-Antibodies: - ANA ... ) 30-45% Differential ... Diagnosis and Lupus ... Mimickers: Drug-induced ... #rheumatology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Exogenous (KCL ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
disease (MCTD), Drug-induced ... Idiopathic Arthritis, Drug-Induced ... Biliary Cirrhosis, Drug-Induced ... #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... erythematosus (ACLE ... permanent alopecia Differential ... La, anti-Jo-1, SCL ... /or medications
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
RA Anti-dsDNA - SLE ... Anti-histone - Drug-induced ... SLE Anti-Jo-1 - ... syndrome Anti-Scl ... diagnosis #table #rheumatology