32 results
Pharmacokinetics of commonly used diuretics medications in CKD, Cirrhotic Ascites, and Heart Failure
 • Furosemide
 •
used diuretics medications ... Spironolactone MCW ... Nephrology @MCW_Nephrology ... #diuretics #pharmacology
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
• Increased renal ... Hypoperfusion • Reduced renal ... release • ↓ Cl ... syndrome #Mechanisms #pathophysiology ... #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
syndrome - Na-K-2Cl ... cotransporter, K channel, Cl ... barrtin (recruits Cl ... Thiazide-sensitive Na—Cl ... Defects #Kidney #Nephrology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... differential #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Pharmacological Treatment of Hepatorenal Syndrome (HRS)

Midodrine - Alpha agonist incr blood pressure incr renal perfusion pressure
pressure incr renal ... edgarvlermamd - Nephrology ... HepatoRenal #Syndrome #Nephrology ... #Management #Pharmacology ... #Medications #Treatment
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
probably < 1500ng/mL ... Best indications ... Special cases (e.g. renal ... Measurement #SLE #rheumatology ... #pharmacology #
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... /min • <60 mL/ ... TerrierBen #Renal ... Vasculitis #Management #Rheumatology ... Cryoglobulinemic #Nephrology
Immunosuppression in Transplantation
Induction (I):
 - Basiliximab (Simulect)
 - Alemtuzumab (Campath)
 - Rituximab
 - Anti-Thymocyte Globulin (ATG)
Induction
Immunosuppressive #Medications ... #Pharmacology # ... Maintenance #Management #Nephrology ... #Renal
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
hyperaldosteronism • Low Urine Cl ... NGT suction, Low Cl ... • High Urine Cl ... hyperaldosteronism • High PRA: Renal ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
hyperaldosteronism • Low Urine Cl ... NGT suction, Low Cl ... • High Urine Cl ... hyperaldosteronism • High PRA: Renal ... Diagnosis #Algorithm #Nephrology