14 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... awaiting confirmatory testing ... Microangiopathy #thrombocytopenic ... HemolyticUremicSyndrome #HUS #thrombocytopenia ... Diagnosis #Table #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... DIC, TTP, HUS - Antibody-mediated ... #Differential # ... Diagnosis #Framework #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... smear, HIV/HCV testing ... changes), high MCV ... or if a primary hematologic ... Causes #Workup #hematology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Testing - Nuclear ... #Antinuclear #Antibody ... #Testing #Nuclear ... Cytoplasmic #Patterns #differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Schistocytes, thrombocytopenia ... Hemolytic #Anemia #Differential ... Algorithm #workup #hematology ... #testing
Platelet Disorders - Differential Diagnosis Framework

Qualitative Defects:
 • Adhesion
 • Aggregation
 • Secretion

Quantitative Defects:
 • Production:
Platelet Disorders - Differential ... Environment-mediated - Antibody-mediated ... Platelet #Disorders #Differential ... #Diagnosis #hematology ... #thrombocytopenia
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
1 or Type 3) — differentiate ... Gplb receptor • Thrombcytopenia ... considered first-line testing ... Platelet #disorders #hematology ... #hemepath #differential
Jaccoud's Arthropathy on Physical Examination

Deforming non-erosive arthropathy characterized by ulnar deviation of the second to fifth
is dependent on resting ... #Arthropathy #MCP ... clinical #video #physicalexam ... #hands #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear ... #Testing #Nuclear ... #Patterns #differential ... #diagnosis #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... hemostasis: - Thrombocytopenia ... Petechiae #Rash #Differential ... Algorithm #Causes #dermatology ... #physicalexam