37 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... sIL-2R >2400 Ul/ml ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... Diagnosis via genetic ... Ferritin >500 ng/mL ... #management #treatment ... #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Diagnosis Algorithm ... CD13, CD33, CD34, HLA-DR ... CD23, o CML ... Blood #Disorders #hematology
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... myelodysplastic #syndrome #differential ... #diagnosis #dermatology ... #oncology #clinical ... #skin
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
• Absence of skin ... min/1.73 m2 at diagnosis ... • Dialysis at diagnosis ... Cryoglobulinemia #Vasculitis #Management ... #Rheumatology #
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... Arthralgia/arthritis, Skin ... fraction < 20% Differential ... #management #treatment ... #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
common in Asia • HLA-B51 ... association • M > F Clinical ... Behcet disease) Differential ... #management #signs ... #symptoms #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... 5000 to 10,000 ng/mL ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Diagnosis of B-Symptoms ... Malignancies (eg CML ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS) - Differential ... Diagnosis Neurologic-Centered ... #Diagnosis #hematology ... #oncology