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diagnosis differential rheumatology myelodysplastic causes chronic eosinophilia hodgkins lymphocytic lymphoma mds monoclonal treatment activation algorithm anemia antinxp2 antinxp2dm aplastic basophilia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
: ALL, CML, AML, ... extramedullary disease ... • Tumor lysis syndrome ... -> Invade Skin: ... #Hematology #Oncology
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
• Eosinophilic Leukemia ... GI, lung, skin), ... Heme malig (AML, CML ... histiocytosis • Allergic ... , Sarcoidosis, SLE
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Hepatomegaly • Skin ... cells can indicate disease ... diagnosis #workup #oncology ... #hematology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
appearing during the disease ... dermatomyositis, SLE ... differential #diagnosis #dermatology ... #oncology #clinical ... #skin
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Allergies): - Allergic ... Rhinitis - Allergic ... Primary: - CML ... Hypereosinophilic Syndrome ... Diagnosis #Causes #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
M spike: • CML ... diseases, CML, ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
total white blood cell ... released during an allergic ... (CML) - associated ... Colitis and Crohn’s Disease ... Diagnosis #causes #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... transformation to acute leukemia ... Allogeneic stem cell ... #treatment #hematology ... #oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... general feeling of ill ... - Allergic contact ... #diagnosis #dermatology ... #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
involved) • No leukemic ... Lymphomas • Other hematologic ... Malignancies (eg CML ... NonHodgkins #comparison #oncology ... #differential #hematology
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