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diagnosis differential causes management classification leukemia cll mcv disorders elevatedmcv lymphocytic macrocytic macrocytosis mds microcytic myelodysplastic thrombocytosis workup aml approach
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Expectation • Rx Algorithm ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss ... RBCs on Smear • Chronic ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Map of proliferative blood disorders. By Ariella Coler-Reilly @ariellastudies #Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
proliferative blood ... ariellastudies #Algorithm ... disorders #leukemia #hematology ... #oncology #diagnosis ... #CML #CLL #AML
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... Non-hemolytic: ACD, Aplastic ... anemia, CKD • ... #MCV #Algorithm ... Differential #Diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Corpuscular Volume (MCV ... Differential Diagnosis Algorithm ... • Marrow Aplasia ... RA, SLE, PRV, Chronic ... #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... Differential Diagnosis Algorithm ... #MCV #Classification ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
of chronic inflammation ... of chronic kidney ... disease, Acute blood ... chronic inflammation ... diagnosis #causes #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... : • Acute or Chronic ... effect following treatment ... Iron deficiency anemia ... #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... blood loss), Vitamin ... deficiencies: Chronic ... marrow failure: Aplastic ... Production #Index #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
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