32 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Anticoagulants #Medications ... #Pharmacology # ... Pathophysiology ... Mechanisms #DOAC #Hematology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Exogenous (KCL ... #hyperkalemia #differential ... #diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Raynaud Phenomenon Differential Diagnosis:

Rheumatologic

 - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD
Heme

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Raynaud Phenomenon Differential ... Diagnosis: Rheumatologic ... - MCC systemic ... , SLE, Sjogren syndrome ... #Differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications ... Thrombocytosis #Platelets #Differential
Serotonin Syndrome Drug Precipitants and Pharmacology
↑ Serotonin Formation: Tryptophan, Oxitriptan
↑ Serotonin Release: Amphetamines, Cocaine, Mirtazapine
↑ Serotonin
Serotonin Syndrome ... Precipitants and Pharmacology ... #Pharmacology # ... medications #causes ... #differential #
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL ... probably < 1500ng/mL ... Best indications ... Measurement #SLE #rheumatology ... #pharmacology #
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis - Differential ... Myelodysplastic syndrome ... myeloid leukemia (CML ... Thrombocytosis #Differential ... Diagnosis #Causes #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
) Low MCV - <80fL ... anemia" High MCV ... Myelodysplastic syndrome ... #differential # ... diagnosis #causes #hematology
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
ileal conduit - Medications ... Multiple myeloma, CML ... rare): - Reye syndrome ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential
Peripheral Edema - Differential Diagnosis Framework for Lower Extremity Edema

Edema occurs when any of the following
Peripheral Edema - Differential ... • SVC syndrome ... insufficiency • Medications ... Peripheral #Edema #differential ... #PhysicalExam #Pathophysiology