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diagnosis hematology differential anemia management mds myelodysplastic thrombocytosis aplastic cancer chronic cll dermatology diffuse endocrinology eosinophilia gout hyperuricemia hypokalemia lad
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... (CML) - Dr. ... #hematology #secondary
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Fatigue • Acute ... #Causes #Hematology ... #Oncology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Differential Diagnosis Algorithm ... Disorders • Acute ... (ALL) • Acute ... (CML) - Hemolytic ... endocrinology #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... bone marrow and secondary ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... transformation to acute ... leukemia Management ... #hematology #oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Chronic Myelogenous Leukemia ... Infectious: • Acute ... effect following treatment ... #Causes #Hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... Primary: - CML ... Mastocytosis - Acute ... Hypereosinophilic Syndrome ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Corpuscular Volume (MCV ... Hypersplenism • Secondary ... Normal RBCs • Acute ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... ’s lymphoma or acute ... • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Chronic Myelogenous Leukemia ... (CML) • Felty ... Cell Leukemia ... #oncology
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