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diagnosis rheumatology differential clinical monkeypox vasculitis dermatology management photo anca mpv mpx lesions lupus algorithm classification comparison druginduced glomerulonephritis mpo
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... #CANCA #PANCA #MPO
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
with someone with Mpox ... inguinal region • Mpox-related ... with confirmed mpox ... Vaccinia virus, Other pox ... #Monkeypox #MPOX
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... (10-40% ANCA +MPO ... 100 % Commonly MPO-ANCA
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
PR3-ANCA 75%, MPO-ANCA ... PR3-ANCA 30%, MPO-ANCA ... - PR3-ANCA 5%, MPO-ANCA ... positivity for MPO ... #sensitivity #MPO
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
MPA > eGPA • MPO-ANCA
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
50% P-ANCA (MPO
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
CD34, HLA-DR, MPO
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
anti-myeloperioxidase (MPO
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
Mpox • Starts
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