126 results
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... - C-ANCA pattern ... antibody) - P-ANCA ... @AnnKumfer #ANCA ... #PANCA #MPO #PR3
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
Frequency of ANCA Positivity in Different Conditions
ANCA-Associated Vasculitis
 • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
75%, MPO-ANCA 20% ... 30%, MPO-ANCA 60% ... 5%, MPO-ANCA 45% ... 10%, MPO-ANCA 80% ... 10%, MPO-ANCA 90%
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis

MPA → usually p-ANCA
GPA → usually c-ANCA
EGPA →
ANCA Associated ... MPA → usually p-ANCA ... EGPA → ANCA in ... 40-50% P-ANCA ... (MPO) C-ANCA (
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
myeloperoxidase (MPO-ANCA ... Granulomas - MPO ... Associated (Commonly MPO-ANCA ... 100 % Commonly MPO-ANCA ... Vasculitis: + MPO-ANCA
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... MPA > eGPA • MPO-ANCA ... (P-ANCA): eGPA,
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
cytoplasmic antibody (ANCA ... ) + • c-ANCA: ... staining • p-ANCA ... anti-myeloperioxidase (MPO
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Pauci Immune (ANCA ... myeloperoxidase (MPO-ANCA ... present in > 30 / MPO ... infiltrates, hemoptysis, MPO ... + MPO) Cryoglobulinemic
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... testing: anti-ANCA ... , anti-GBM ab, ANA