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diagnosis algorithm treatment pharmacology criticalcare gastroenterology checklist cardiology peds table differential medications pediatrics pulmonary covid19 primarycare guidelines syndrome clinical comparison
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
with someone with Mpox ... inguinal region • Mpox-related ... with confirmed mpox ... #Monkeypox #MPOX ... #Diagnosis #Management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... - pANCA anti-MPO ... Usual therapeutic management ... Erythematosus #Diagnosis #Management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
- pANCA anti-MPO ... - pANCA anti-MPO ... Usual therapeutic management ... rheumatology #diagnosis #management
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... #CANCA #PANCA #MPO
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... (10-40% ANCA +MPO ... 100 % Commonly MPO-ANCA
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
MPA > eGPA • MPO-ANCA
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
CD34, HLA-DR, MPO
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
50% P-ANCA (MPO
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
anti-myeloperioxidase (MPO
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