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diagnosis dermatology clinical differential management algorithm rheumatology hepatology photo causes skinrash ucsdh physicalexam treatment video skin rash pathophysiology comparison table
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... PR3 #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
C-ANCA): GPA >>> MPA ... > eGPA • MPO-ANCA ... P-ANCA): eGPA, MPA ... diagnosis #algorithm #rheumatology
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
PR3-ANCA 75%, MPO-ANCA ... PR3-ANCA 30%, MPO-ANCA ... positivity for MPO ... #sensitivity #MPO ... PR3 #diagnosis #rheumatology
Lesions in Persons with Confirmed Human Monkeypox Virus Infection A) Evolution of Cutaneous Lesions B) Oral and Perioral
Rectal Lesions #MPV ... #MPX #clinical ... lesions #monkeypox #dermatology
Appearance of Monkeypox Primary Inoculation Reactions #Monkeypox #MPV #MPX #lesions #clinical #Inoculation #photo
#Monkeypox #MPV ... #MPX #lesions #
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
CD34, HLA-DR, MPO ... Polycythemia Vera (PV ... Blood #Disorders #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... (10-40% ANCA +MPO ... myeloperoxidase (MPO
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
Differential Diagnosis MPA ... 50% P-ANCA (MPO
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... Labs: anemia, ↑ MCV ... Diagnosis #Algorithm #hematology
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