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Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... • Burns Non malignant ... malignancy • ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... Tissue, Infections, Malignancy ... Lymphocytosis: Infection, Malignancy ... Differential #Diagnosis #causes ... #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... compression and DVT MALIGNANCY ... APLS:PLT ↓ HEMATOLOGIC ... Diagnosis #clots #hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... : • Thoracic Malignancy ... • Abdominal Malignancy ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Non-infectious (malignancy ... Differential #Diagnosis #causes ... #Platelets #hematology
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Causes of Hyperferritinemia ... Most Common Causes ... Malignancy - 24% ... 1% Most Common Causes ... Hematologic Malignancy
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Causes of Splenomegaly ... Infiltrative - Non-Malignant ... Infiltrative - Malignant ... Diagnosis #Algorithm #Causes ... #Hematology
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
Dangerous secondary causes ... pass = Primary Causes ... Mastocytosis • Other hematologic ... malignancy ... Differential #Diagnosis #hematology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... , EBV, CMV • Malignancy ... : - Hematologic ... vasculitis to cause ... Differential #Diagnosis #causes
Conditions Associated With Hyperferritinemia DDx of extreme hyperferritinemia >10,000 Not just HLH - in fact, most common
fact, most common causes ... Heme malignancy ... Liver Disease - Malignancy—Hematologic ... - Solid Malignancy ... differential #diagnosis #causes
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