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diagnosis differential hematology management algorithm treatment hivaids idsa opportunistic prevention anemia oncology syndrome classification dermatology thrombocytopenia bacterial disorders eosinophilia eosinophils
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... Malignancy, Autimmune, Drugs ... , Drugs, Autoimmune ... Differential #Diagnosis #causes ... #hematology
Eosinophils (Eos) and hypereosinophilia (HE) Caused by eosinophilopoietic cytokines Common causes: - Drug reaction - Helminth infection -
cytokines Common causes ... : - Drug reaction ... - Helminth infection ... CD3-CD4+ T cells ... aspergillosis - Viral infections
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... (e.g. cancer, infection ... suppression (e.g. drugs ... G6PD deficiency), Infections
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... malignancies • Infection ... Radiation • Drugs ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... Vasculitis • Infection ... #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Pseudotumor - Infectious ... History of Bleeding, Infection ... Lymphocytic Leukemia (CBC ... #Hematology #Oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... →Activation of CD8 ... immune deficiency, Drugs ... , Unknown cause ... treatment #summary #rheumatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Artifact (redo CBC ... Myelofibrosis Infectious ... Diagnosis #Algorithm #Causes ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
: - Drug induced ... SLE) - Viral infections ... APLS • Acute Infectious ... spotted fever • Drug ... #rheumatology #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... delayed HTR • Drug-induced ... circulation - Infections ... Diagnosis #Algorithm #Causes ... #Hematology
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